1 Despite this prospect, COPD remains often undiagnosed and untreated until the disease has progressed to a point where lung function and quality of life are severely affected. Nowadays, it is associated with multiple and significant morbidity and increased mortality. These findings reinforce the importance of early diagnosis of COPD and assessment of more than just spirometry.Ĭhronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of the airways and lungs, persistent airflow limitation and, often, a progressive decline in lung function. Physical activity level is not yet reduced, but many patients already experience limitations in health status. Significant ventilatory constraints already occur in early-stage COPD patients during common ADL and result in increased dyspnoea. From the patients, 55–84% experienced mild-to-severe problems in health status compared with 5–25% of the controls. Physical activity was low but comparable between both groups. Higher dyspnoea was scored by patients with dynamic hyperinflation. Compared with controls, COPD patients had greater ventilatory inefficiency and higher ventilatory requirements during ADL ( P50% of the patients developed dynamic hyperinflation in contrast to 10–35% of the controls. Health status was assessed by the Nijmegen Clinical Screening Instrument. Physical activity was measured with accelerometry. Respiratory mechanics were measured during ADL. 12% predicted) and 20 controls performed 3 ADL: climbing stairs, vacuum cleaning and displacing groceries in a cupboard. In this cross-sectional study, 39 early-stage COPD patients (mean FEV 1 88±s.d. The aim of this study was to assess respiratory mechanics during ADL and to study its consequences on dyspnoea, physical activity and health status in early-stage COPD compared with healthy controls. It is unknown whether ventilatory constraints occur during activities of daily life (ADL) in early stages of COPD. In patients with chronic obstructive pulmonary disease (COPD), exercise capacity is reduced, resulting over time in physical inactivity and worsened health status.
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